Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure

Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure

Abstract Acute liver failure (ALF) is a severe life-threatening disease associated with the disorder of the gut-liver axis. However, the cellular characteristics of ALF in the gut and related therapeutic targets remain unexplored. Here, we utilized the D-GALN/LPS (D/L)-induced ALF model to character...

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Bibliographic Details
Main Authors: Jie Yin, Ziming Zhao, Jianzheng Huang, Yang Xiao, Mewlude Rehmutulla, Biqiong Zhang, Zijun Zhang, Ming Xiang, Qingyi Tong, Yonghui Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00578-4

Internet

https://doi.org/10.1038/s41421-023-00578-4

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