Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.

There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using fluorescent reporters for the expression of Nanog, we observed that a population of ES cells is best described by...

Full description

Bibliographic Details
Main Authors: Tibor Kalmar, Chea Lim, Penelope Hayward, Silvia Muñoz-Descalzo, Jennifer Nichols, Jordi Garcia-Ojalvo, Alfonso Martinez Arias
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19582141/pdf/?tool=EBI