Selective HDAC inhibition for the disruption of latent HIV-1 infection.

Selective HDAC inhibition for the disruption of latent HIV-1 infection.

Selective histone deacetylase (HDAC) inhibitors have emerged as a potential anti-latency therapy for persistent human immunodeficiency virus type 1 (HIV-1) infection. We utilized a combination of small molecule inhibitors and short hairpin (sh)RNA-mediated gene knockdown strategies to delineate the...

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Bibliographic Details
Main Authors: Kirston M Barton, Nancie M Archin, Kara S Keedy, Amy S Espeseth, Yan-ling Zhang, Jennifer Gale, Florence F Wagner, Edward B Holson, David M Margolis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4138023?pdf=render

Internet

http://europepmc.org/articles/PMC4138023?pdf=render

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