Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer’s disease

Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer’s disease

Abstract Breakdown of the neurovascular unit is associated with blood-brain barrier (BBB) leakiness contributing to cognitive decline and disease pathology in the early stages of Alzheimer’s disease (AD). Vascular stability depends on angiopoietin-1 (ANGPT-1) signalling, antagonised by angiopoietin-...

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Bibliographic Details
Main Authors: Carol Van Hulle, Selvi Ince, Ozioma C. Okonkwo, Barbara B. Bendlin, Sterling C. Johnson, Cynthia M. Carlsson, Sanjay Asthana, Seth Love, Kaj Blennow, Henrik Zetterberg, J. Scott Miners
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02706-w

Internet

https://doi.org/10.1038/s41398-023-02706-w

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