Epigenetic Targets for Oligonucleotide Therapies of Pulmonary Arterial Hypertension

Epigenetic Targets for Oligonucleotide Therapies of Pulmonary Arterial Hypertension

Arterial wall remodeling underlies increased pulmonary vascular resistance and right heart failure in pulmonary arterial hypertension (PAH). None of the established vasodilator drug therapies for PAH prevents or reverse established arterial wall thickening, stiffening, and hypercontractility. Theref...

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Bibliographic Details
Main Author: William Gerthoffer
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
DNA methylation
histone code
microRNA
nanoparticles
noncoding RNA
pulmonary arterial hypertension
Online Access:https://www.mdpi.com/1422-0067/21/23/9222

Internet

https://www.mdpi.com/1422-0067/21/23/9222

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