PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis.

PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis.

Sepsis severity has been positively correlated with platelet dysfunction, which may be due to elevations in nitric oxide (NO) and cGMP levels. Protein kinase C, Src kinases, PI3K and AKT modulate platelet activity in physiological conditions, but no studies evaluated the role of these enzymes in pla...

Full description

Bibliographic Details
Main Authors: M Elisa Lopes-Pires, Ana C Antunes Naime, Nádia J Almeida Cardelli, Débora J Anjos, Edson Antunes, Sisi Marcondes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4573322?pdf=render

Internet

http://europepmc.org/articles/PMC4573322?pdf=render

Similar Items