Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types

Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types

Abstract Background The T cell-inflamed tumor microenvironment, characterized by CD8 T cells and type I/II interferon transcripts, is an important cancer immunotherapy biomarker. Tumor mutational burden (TMB) may also dictate response, and some oncogenes (i.e., WNT/β-catenin) are known to mediate im...

Full description

Bibliographic Details
Main Authors: Riyue Bao, Daniel Stapor, Jason J. Luke
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Genome Medicine
Subjects:
T cell-inflamed
Immune evasion
Genomics
Transcriptomics
TCGA
Online Access:http://link.springer.com/article/10.1186/s13073-020-00787-6

Internet

http://link.springer.com/article/10.1186/s13073-020-00787-6

Similar Items