A prime editor efficiently repaired human induced pluripotent stem cells with AR gene mutation (c.2710G > A; p. V904M)

A prime editor efficiently repaired human induced pluripotent stem cells with AR gene mutation (c.2710G > A; p. V904M)

Prime Editor (PE) is a precise genome manipulation technology based on the CRISPR-Cas9 system, while its application in human induced pluripotent stem cells (iPSCs) remains limited. Here, we established a repaired hiPS cell line (SKLRMi001-A-1) from hiPSCs with androgen receptor (AR) mutation (c.271...

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Bibliographic Details
Main Authors: Ruiqi Sun, Yiqiang Cui, Zhaode Liu, Jiayin Guo, Xin Zhang, Pinmou Zhu, Jiahao Sha, Xiaoyu Yang, Yan Yuan
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Stem Cell Research
Subjects:
Induced pluripotent stem cell
Gene editing
Androgen insensitivity syndrome
Prime editors
CRISPR-Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506123000880

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http://www.sciencedirect.com/science/article/pii/S1873506123000880

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