Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells

Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells

Abstract Background Both humoral and cellular immune mechanisms are involved in the onset and progression of autoimmune responses in systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of SLE via the dysregulation of type I interferon (IFN)...

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Main Authors: Minoru Shigesaka, Tomoki Ito, Muneo Inaba, Kai Imai, Hideki Yamanaka, Yoshiko Azuma, Akihiro Tanaka, Hideki Amuro, Tohru Nishizawa, Yonsu Son, Atsushi Satake, Yoshio Ozaki, Shosaku Nomura
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Arthritis Research & Therapy
Subjects:
SLE
Plasmacytoid DCs
Myeloid DCs
Type I IFN
MPA
IRF7
Online Access:http://link.springer.com/article/10.1186/s13075-020-02356-z

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http://link.springer.com/article/10.1186/s13075-020-02356-z

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