Federated generalized linear mixed models for collaborative genome-wide association studies

Summary: Federated association testing is a powerful approach to conduct large-scale association studies where sites share intermediate statistics through a central server. There are, however, several standing challenges. Confounding factors like population stratification should be carefully modeled...

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Bibliographic Details
Main Authors: Wentao Li, Han Chen, Xiaoqian Jiang, Arif Harmanci
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223013044