Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

Adhesion-type G protein-coupled receptors (aGPCRs), a large molecule family with over 30 members in humans, operate in organ development, brain function and govern immunological responses. Correspondingly, this receptor family is linked to a multitude of diverse human diseases. aGPCRs have been sugg...

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Bibliographic Details
Main Authors: Nicole Scholz, Chonglin Guan, Matthias Nieberler, Alexander Grotemeyer, Isabella Maiellaro, Shiqiang Gao, Sebastian Beck, Matthias Pawlak, Markus Sauer, Esther Asan, Sven Rothemund, Jana Winkler, Simone Prömel, Georg Nagel, Tobias Langenhan, Robert J Kittel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
adhesion GPCR
mechanotransduction
metabotropic signalling
sensory physiology
dCIRL
Latrophilin
Online Access:https://elifesciences.org/articles/28360

Internet

https://elifesciences.org/articles/28360

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