Rotundic acid improves nonalcoholic steatohepatitis in mice by regulating glycolysis and the TLR4/AP1 signaling pathway

Rotundic acid improves nonalcoholic steatohepatitis in mice by regulating glycolysis and the TLR4/AP1 signaling pathway

Abstract Background Steatosis and inflammation are the hallmarks of nonalcoholic steatohepatitis (NASH). Rotundic acid (RA) is among the key triterpenes of Ilicis Rotundae Cortex and has exhibited multipronged effects in terms of lowering the lipid content and alleviating inflammation. The study obj...

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Bibliographic Details
Main Authors: Xing-Yang Shi, Xiao-Min Zheng, Hui-Jie Liu, Xue Han, Lei Zhang, Bei Hu, Shan Li
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Lipids in Health and Disease
Subjects:
NASH
RA
Glycolysis
TLR4/AP1
Proteomics
Transcriptomics
Online Access:https://doi.org/10.1186/s12944-023-01976-z

Internet

https://doi.org/10.1186/s12944-023-01976-z

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