Dehydrocostus lactone inhibits the proliferation and metastasis of hepatocellular carcinoma cells via modulating p53-p21-CDK2 signaling pathway

Dehydrocostus lactone inhibits the proliferation and metastasis of hepatocellular carcinoma cells via modulating p53-p21-CDK2 signaling pathway

Background: Hepatocellular carcinoma (HCC), a malignancy with high mortality and recurrence rates, has very limited options for treatment strategies. Dehydrocostus lactone (DL) is the principal quality marker extracted from Aucklandia lappa Decne. and has been demonstrated to possess excellent antic...

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Bibliographic Details
Main Authors: Yingying Tian, Beibei Ma, Xinyue Zhao, Shiqiu Tian, Yilin Li, Hailuan Pei, Shangyue Yu, Chuang Liu, Zhaozhou Lin, Zeping Zuo, Zhibin Wang
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Arabian Journal of Chemistry
Subjects:
Dehydrocostus lactone (DL)
hepatocellular carcinoma (HCC)
Proliferation
Apoptosis
Metastasis
p53-p21-CDK2
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223004562

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http://www.sciencedirect.com/science/article/pii/S1878535223004562

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