Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats

Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats

Introduction: Previous studies in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX) have shown that besides pharmacological blockade of the renin-angiotensin system (RAS) also increasing kidney tissue epoxyeicosatrienoic acids (EET) levels by blocking soluble epoxide hydrola...

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Bibliographic Details
Main Authors: Věra Čertíková Chábová, Petr Kujal, Zdeňka Vaňourková, Petra Škaroupková, Janusz Sadowski, Elzbieta Kompanowska-Jezierska, Vladimír Tesař, Bruce Hammock, John Imig, Hana Maxová, Luděk Červenka, Ivana Vaněčková
Format: Article
Language:English
Published: Karger Publishers 2019-11-01
Series:Kidney & Blood Pressure Research
Subjects:
chronic kidney disease
5/6 renal mass reduction
hypertension
soluble epoxide hydrolase inhibitor
renin-angiotensin system
endothelin a receptor blocker
Online Access:https://www.karger.com/Article/FullText/504137

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https://www.karger.com/Article/FullText/504137

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