Abnormalities associated with progressive aortic vascular dysfunction in chronic kidney disease

Increased stiffness of large arteries in chronic kidney disease (CKD) has significant clinical implications. This study investigates the temporal development of thoracic aortic dysfunction in a rodent model of CKD, the Lewis polycystic kidney (LPK) rat. Animals aged 12 and 18 weeks were studied alon...

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Bibliographic Details
Main Authors: Omar Z Ameer, Rochelle eBoyd, Mark eButlin, Alberto P Avolio, Jacqueline Kathleen Phillips
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00150/full