The molecular basis of JAK/STAT inhibition by SOCS1

The molecular basis of JAK/STAT inhibition by SOCS1

Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanation for the potent JAK- inhibitory activity of SOC...

Full description

Bibliographic Details
Main Authors: Nicholas P. D. Liau, Artem Laktyushin, Isabelle S. Lucet, James M. Murphy, Shenggen Yao, Eden Whitlock, Kimberley Callaghan, Nicos A. Nicola, Nadia J. Kershaw, Jeffrey J. Babon
Format: Article
Language:English
Published: Nature Portfolio 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04013-1

Internet

https://doi.org/10.1038/s41467-018-04013-1

Similar Items