Rapid measurement of deuterium-labeled long-chain fatty acids in plasma by HPLC-ESI-MS

Rapid measurement of deuterium-labeled long-chain fatty acids in plasma by HPLC-ESI-MS

Imbalanced fatty acid metabolism contributes significantly to the increased incidence of metabolic disorders. Isotope-labeled fatty acids (2H, 13C) provide efficient means to trace fatty acid metabolism in vivo. This study reports a new and rapid method for the quantification of deuterium-labeled fa...

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Bibliographic Details
Main Authors: Sébastien Gagné, Sheldon Crane, Zheng Huang, Chun Sing Li, Kevin P. Bateman, Jean-François Lévesque
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Journal of Lipid Research
Subjects:
deuterium-labeled stearic acid
deuterium-labeled oleic acid
deuterium-labeled palmitic acid
high-performance liquid chromatography-electrospray ionization-mass spectrometry
electrospray ionization negative mode
quantification of plasma levels
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520436570

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http://www.sciencedirect.com/science/article/pii/S0022227520436570

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