A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

Staphylococcus aureus infections are associated with high mortality rates. Often considered an extracellular pathogen, S. aureus can persist and replicate within host cells, evading immune responses, and causing host cell death. Classical methods for assessing S. aureus cytotoxicity are limited by t...

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Bibliographic Details
Main Authors: Abderrahman Hachani, Stefano G Giulieri, Romain Guérillot, Calum J Walsh, Marion Herisse, Ye Mon Soe, Sarah L Baines, David R Thomas, Shane Doris Cheung, Ashleigh S Hayes, Ellie Cho, Hayley J Newton, Sacha Pidot, Ruth C Massey, Benjamin P Howden, Timothy P Stinear
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
Staphylococcus aureus
bacterial population genomics
evolutionary convergence analysis
intracellular
cytotoxicity
GWAS
Online Access:https://elifesciences.org/articles/84778

Internet

https://elifesciences.org/articles/84778

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