Hypoxia promotes the migration and invasion of human hepatocarcinoma cells through the HIF-1α–IL-8–Akt axis

Hypoxia promotes the migration and invasion of human hepatocarcinoma cells through the HIF-1α–IL-8–Akt axis

Abstract Background Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. The 5-year survival rate remains low despite considerable research into treatments of HCC, including surgery, radiotherapy and chemotherapy. Many mech...

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Bibliographic Details
Main Authors: Maoyun Fei, Jianming Guan, Tao Xue, Lianjin Qin, Chengwu Tang, Ge Cui, Yao Wang, Hui Gong, Wenming Feng
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Cellular & Molecular Biology Letters
Subjects:
Hepatocarcinoma
Hypoxia
HIF-1α
IL-8
Akt pathway
Online Access:http://link.springer.com/article/10.1186/s11658-018-0100-6

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http://link.springer.com/article/10.1186/s11658-018-0100-6

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