A live attenuated RHΔompdcΔuprt mutant of Toxoplasma gondii induces strong protective immunity against toxoplasmosis in mice and cats

A live attenuated RHΔompdcΔuprt mutant of Toxoplasma gondii induces strong protective immunity against toxoplasmosis in mice and cats

Abstract Background Toxoplasma gondii is an obligate intracellular apicomplexan parasite and is responsible for zoonotic toxoplasmosis. It is essential to develop an effective anti-T. gondii vaccine for the control of toxoplasmosis, and this study is to explore the immunoprotective effects of a live...

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Bibliographic Details
Main Authors: Yu Shen, Bin Zheng, Hao Sun, Songrui Wu, Jiyuan Fan, Jianzu Ding, Meng Gao, Qingming Kong, Di Lou, Haojie Ding, Xunhui Zhuo, Shaohong Lu
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Infectious Diseases of Poverty
Subjects:
Toxoplasma gondii
Orotidine-5'-monophosphate decarboxylase
Phosphoribosyltransferase
Live attenuated vaccine
Immunization
Mouse
Online Access:https://doi.org/10.1186/s40249-023-01109-9

Internet

https://doi.org/10.1186/s40249-023-01109-9

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