Suppression of PD‐L1 release from small extracellular vesicles promotes systemic anti‐tumor immunity by targeting ORAI1 calcium channels

Abstract Blockade of immune checkpoints as a strategy of cancer cells to overcome the immune response has received ample attention in cancer research recently. In particular, expression of PD‐L1 by various cancer cells has become a paradigm in this respect. Delivery of PD‐L1 to its site of action oc...

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Bibliographic Details
Main Authors: Xi Chen, Jiaqi Li, Ren Zhang, Yao Zhang, Xiaoxuan Wang, Elaine Lai‐Han Leung, Lijuan Ma, Vincent Kam Wai Wong, Liang Liu, Erwin Neher, Haijie Yu
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Journal of Extracellular Vesicles
Subjects:
Online Access:https://doi.org/10.1002/jev2.12279