Suppression of PD‐L1 release from small extracellular vesicles promotes systemic anti‐tumor immunity by targeting ORAI1 calcium channels

Suppression of PD‐L1 release from small extracellular vesicles promotes systemic anti‐tumor immunity by targeting ORAI1 calcium channels

Abstract Blockade of immune checkpoints as a strategy of cancer cells to overcome the immune response has received ample attention in cancer research recently. In particular, expression of PD‐L1 by various cancer cells has become a paradigm in this respect. Delivery of PD‐L1 to its site of action oc...

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Bibliographic Details
Main Authors: Xi Chen, Jiaqi Li, Ren Zhang, Yao Zhang, Xiaoxuan Wang, Elaine Lai‐Han Leung, Lijuan Ma, Vincent Kam Wai Wong, Liang Liu, Erwin Neher, Haijie Yu
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Journal of Extracellular Vesicles
Subjects:
Ca2+
ORAI1
PD‐L1
exosome
lung cancer
Online Access:https://doi.org/10.1002/jev2.12279

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