BRD4 promotes heterotopic ossification through upregulation of LncRNA MANCR

BRD4 promotes heterotopic ossification through upregulation of LncRNA MANCR

Aims: Acquired heterotopic ossification (HO) is a debilitating disease characterized by abnormal extraskeletal bone formation within soft-tissues after injury. The exact pathogenesis of HO remains unknown. It was reported that BRD4 may contribute to osteoblastic differentiation. The current study ai...

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Bibliographic Details
Main Authors: Lei Liu, ZiHao Li, Siwen Chen, Haowen Cui, Xiang Li, Guo Dai, Fangling Zhong, Wenjun Hao, Kuibo Zhang, Hui Liu
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2021-10-01
Series:Bone & Joint Research
Subjects:
brd4
mancr
osteogenesis
jq1
heterotopic ossification
heterotopic ossification (ho)
staining
rnas
quantitative polymerase chain reaction
bone formation
mesenchymal stem cells (mscs)
achilles tendons
western blot
bone marrow
pathogenesis
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1010.BJR-2020-0454.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1010.BJR-2020-0454.R1

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