Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases

Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases

Abstract Background Niemann–Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body’s endogenous cholesterol...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Mark L. Schultz, Maria V. Fawaz, Ruth D. Azaria, Todd C. Hollon, Elaine A. Liu, Thaddeus J. Kunkel, Troy A. Halseth, Kelsey L. Krus, Ran Ming, Emily E. Morin, Hayley S. McLoughlin, David D. Bushart, Henry L. Paulson, Vikram G. Shakkottai, Daniel A. Orringer, Anna S. Schwendeman, Andrew P. Lieberman
التنسيق: مقال
اللغة:English
منشور في: BMC 2019-11-01
سلاسل:BMC Medicine
الموضوعات:
Niemann–Pick C
NPC1
HDL
SRS
Niemann–Pick A
الوصول للمادة أونلاين:http://link.springer.com/article/10.1186/s12916-019-1423-5

الانترنت

http://link.springer.com/article/10.1186/s12916-019-1423-5

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