Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover

Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover

Abstract Background Prostate cancer growth is driven by androgen receptor signaling, and advanced disease is initially treatable by depleting circulating androgens. However, prostate cancer cells inevitably adapt, resulting in disease relapse with incurable castrate-resistant prostate cancer. Androg...

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Bibliographic Details
Main Authors: Nikki L. Raftopulos, Tinashe C. Washaya, Andreas Niederprüm, Antonia Egert, Mariam F. Hakeem-Sanni, Bianca Varney, Atqiya Aishah, Mariya L. Georgieva, Ellinor Olsson, Diandra Z. dos Santos, Zeyad D. Nassar, Blake J. Cochran, Shilpa R. Nagarajan, Meghna S. Kakani, Jordan F. Hastings, David R. Croucher, Kerry-Anne Rye, Lisa M. Butler, Thomas Grewal, Andrew J. Hoy
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Cancer & Metabolism
Subjects:
Prostate cancer
LDL
LDL-cholesterol
Cell proliferation
Cholesteryl ester
ACAT1
Online Access:https://doi.org/10.1186/s40170-021-00278-1

Internet

https://doi.org/10.1186/s40170-021-00278-1

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