Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome

Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome

L-type calcium channel CaV1.2 plays an essential role in cardiac function. The gain-of-function mutations in CaV1.2 have been reported to be associated with Timothy syndrome, a disease characterized by QT prolongation and syndactyly. Previously we demonstrated that roscovitine, a cyclin-dependent ki...

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Bibliographic Details
Main Authors: LouJin Song, Seon-hye E. Park, Yehuda Isseroff, Kumi Morikawa, Masayuki Yazawa
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Stem Cell Reports
Subjects:
cardiac arrhythmia
iPSC
disease modeling
calcium handling
drug test
Timothy syndrome
CDK5
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302357

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http://www.sciencedirect.com/science/article/pii/S2213671117302357

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