Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome
L-type calcium channel CaV1.2 plays an essential role in cardiac function. The gain-of-function mutations in CaV1.2 have been reported to be associated with Timothy syndrome, a disease characterized by QT prolongation and syndactyly. Previously we demonstrated that roscovitine, a cyclin-dependent ki...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-07-01
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Series: | Stem Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213671117302357 |