ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors

ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors

Abstract Background ATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a number of signaling pathways including regulation of oxidative stress response and metabolic diversion of glucose through the pentose phosphate...

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Bibliographic Details
Main Authors: Cristina Terlizzi, Viviana De Rosa, Francesca Iommelli, Antonio Pezone, Giovanna G. Altobelli, Maurizio Maddalena, Jelena Dimitrov, Caterina De Rosa, Carminia Maria Della Corte, Vittorio Enrico Avvedimento, Silvana Del Vecchio
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cancer & Metabolism
Subjects:
ATM
Glycolysis
OXPHOS
Oncogene-driver inhibitors
Anticancer therapy
Online Access:https://doi.org/10.1186/s40170-023-00320-4

Internet

https://doi.org/10.1186/s40170-023-00320-4

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