Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice

Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice

Song, Chang et al. identify miR-494-3p as a protector of colitis in mice. They find that a cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and its ligand EDA-A2 derived from macrophages, suppresses colonic stemness and epithelial repair in colitis crypts. This study illustrates how macrophage-...

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Bibliographic Details
Main Authors: Lele Song, Renxu Chang, Xia Sun, Liying Lu, Han Gao, Huiying Lu, Ritian Lin, Xiaorong Xu, Zhanju Liu, Lixing Zhan
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01730-0

Internet

https://doi.org/10.1038/s42003-021-01730-0

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