Proton pump inhibitor treatment aggravates bacterial translocation in patients with advanced cirrhosis and portal hypertension

Proton pump inhibitor treatment aggravates bacterial translocation in patients with advanced cirrhosis and portal hypertension

ABSTRACT Recent studies have linked proton pump inhibitor (PPI) treatment to increased complications of cirrhosis, such as bacterial infections and hepatic encephalopathy. However, the underlying pathophysiological mechanisms remain unclear. The present study investigated the hypothesis that PPI tre...

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Bibliographic Details
Main Authors: Lukas Sturm, Misa Hirose, Laura Stolz, Michael Schultheiss, Katharina Zoldan, Marlene Reincke, Jan Patrick Huber, Rafael Kaeser, Tobias Boettler, Robert Thimme, Elisabeth Albert, Hauke Busch, Axel Künstner, Dominik Bettinger
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
bacterial translocation
cirrhosis
portal hypertension
proton pump inhibitor
microbiome
Online Access:https://journals.asm.org/doi/10.1128/mbio.00492-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00492-23

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