Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds.

Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds.

Human African trypanosomiasis is caused by the eukaryotic microbe Trypanosoma brucei. To discover new drugs against the disease, one may use drugs in the clinic for other indications whose chemical scaffolds can be optimized via a medicinal chemistry campaign to achieve greater potency against the t...

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Bibliographic Details
Main Authors: Samiksha Katiyar, Irina Kufareva, Ranjan Behera, Sarah M Thomas, Yuko Ogata, Michael Pollastri, Ruben Abagyan, Kojo Mensa-Wilmot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3577790?pdf=render

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http://europepmc.org/articles/PMC3577790?pdf=render

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