A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease

A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease

Abstract Many aging individuals accumulate the pathology of Alzheimer’s disease (AD) without evidence of cognitive decline. Here we describe an integrated neurodegeneration checkpoint response to early pathological changes that restricts further disease progression and preserves cognitive function....

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Bibliographic Details
Main Authors: Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A. Fernandez, Perle Roche, Emma L. Bunting, Ella K. Lacey, Sara E. Hamplova, Monlan Yuan, Michael S. Wolfe, David A. Bennett, Eunjung A. Lee, Bruce A. Yankner
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42704-6

Internet

https://doi.org/10.1038/s41467-023-42704-6

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