Live Vaccination with Blood-Stage <i>Plasmodium yoelii</i> 17XNL Prevents the Development of Experimental Cerebral Malaria

Live Vaccination with Blood-Stage <i>Plasmodium yoelii</i> 17XNL Prevents the Development of Experimental Cerebral Malaria

In our work, we aim to develop a malaria vaccine with cross-strain (-species) protection. C57BL/6 mice infected with the <i>P. berghei</i> ANKA strain (PbA) develop experimental cerebral malaria (ECM). In contrast, ECM development is inhibited in infected mice depleted of T cells. The cl...

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Bibliographic Details
Main Authors: Takashi Imai, Ha Ngo-Thanh, Kazutomo Suzue, Aoi Shimo, Akihiro Nakamura, Yutaka Horiuchi, Hajime Hisaeda, Takashi Murakami
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Vaccines
Subjects:
malaria
experimental cerebral malaria
live vaccination
inflammatory response
blood–brain barrier
Online Access:https://www.mdpi.com/2076-393X/10/5/762

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https://www.mdpi.com/2076-393X/10/5/762

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