Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF

Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF

In this study we tested whether phosphodiesterase 5 (PDE5) inhibitors, sildenafil and vardenafil, would afford protection against 3-nitropropionic acid (3NP), which produces striatal lesions that closely mimic some of the neuropathological features of Huntington's Disease (HD). The neurotoxin w...

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Bibliographic Details
Main Authors: Elena Puerta, Isabel Hervias, Lucía Barros-Miñones, Joaquin Jordan, Ana Ricobaraza, Mar Cuadrado-Tejedor, Ana García-Osta, Norberto Aguirre
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Neurobiology of Disease
Subjects:
3-Nitropropionic acid
BDNF
Calpain
CREB
Excitotoxicity
Huntington's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611000015X

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http://www.sciencedirect.com/science/article/pii/S096999611000015X

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