The Role of Genetic Polymorphisms in High-Dose Methotrexate Toxicity and Response in Hematological Malignancies: A Systematic Review and Meta-Analysis

The Role of Genetic Polymorphisms in High-Dose Methotrexate Toxicity and Response in Hematological Malignancies: A Systematic Review and Meta-Analysis

Objective: High-dose methotrexate (HDMTX) is a mainstay therapeutic agent for the treatment of diverse hematological malignancies, and it plays a significant role in interindividual variability regarding the pharmacokinetics and toxicity. The genetic association of HDMTX has been widely investigated...

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Bibliographic Details
Main Authors: Zaiwei Song, Yang Hu, Shuang Liu, Dan Jiang, Zhanmiao Yi, Mason M. Benjamin, Rongsheng Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
methotrexate
pharmacogenetics
polymorphism
toxicity
hematological malignancies
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.757464/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.757464/full

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