Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression

Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression

Cardiac hypertrophy is an adaptive response to various pathological insults, including hypertension. However, sustained hypertrophy can cause impaired calcium regulation, cardiac dysfunction, and remodeling, accompanied by cardiac fibrosis. Our previous study identified miR-25 as a regulator of SERC...

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Bibliographic Details
Main Authors: Cholong Lee, Sunghye Cho, Dongtak Jeong
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
cardiac dysfunction
hypertension
cardiac hypertrophy
cardiac fibrosis
miR-25
KLF4
Online Access:https://www.mdpi.com/1422-0067/24/15/12434

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https://www.mdpi.com/1422-0067/24/15/12434

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