Mechanistic study of silica nanoparticles on the size-dependent retinal toxicity in vitro and in vivo

Mechanistic study of silica nanoparticles on the size-dependent retinal toxicity in vitro and in vivo

Abstract Background Silica nanoparticles (SiO2 NPs) are extensively applied in the biomedical field. The increasing medical application of SiO2 NPs has raised concerns about their safety. However, studies on SiO2 NP-induced retinal toxicity are lacking. Methods We investigated the retinal toxicity o...

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Bibliographic Details
Main Authors: Zhuhong Zhang, Laien Zhao, Yuanyuan Ma, Jia Liu, Yanmei Huang, Xiaoxuan Fu, Shengjun Peng, Xiaojie Wang, Yun Yang, Xiaoyan Zhang, Wanru Ding, Jinguo Yu, Yanping Zhu, Hua Yan, Shubin Yang
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Nanobiotechnology
Subjects:
SiO2 NPs
Retinal toxicity
ROS
Ganglion cell degeneration
Glial cell activation
Inflammation
Online Access:https://doi.org/10.1186/s12951-022-01326-8

Internet

https://doi.org/10.1186/s12951-022-01326-8

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