MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment

MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment

Abstract Background The bone marrow (BM) is the most common site of dissemination in patients with aggressive, metastatic neuroblastoma (NB). However, the molecular mechanisms underlying the aggressive behavior of NB cells in the BM niche are still greatly unknown. In the present study, we explored...

Full description

Bibliographic Details
Main Authors: Laura Garcia-Gerique, Marta García, Alícia Garrido-Garcia, Soledad Gómez-González, Montserrat Torrebadell, Estela Prada, Guillem Pascual-Pasto, Oscar Muñoz, Sara Perez-Jaume, Isadora Lemos, Noelia Salvador, Monica Vila-Ubach, Ana Doncel-Requena, Mariona Suñol, Angel M. Carcaboso, Jaume Mora, Cinzia Lavarino
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Cancer
Subjects:
Neuroblastoma
Bone marrow
MIF
CXCR4
Hypoxia
4-IPP
Online Access:https://doi.org/10.1186/s12885-022-09725-8

Internet

https://doi.org/10.1186/s12885-022-09725-8

Similar Items