Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C

Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C

Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosin-2 isoforms. Here, we present a 2.25 Å pre-powerstroke state (ADP⋅VO4) crystal structure of the human nonmuscle myosin-2C motor domain, one of the slowest myosins charac...

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Bibliographic Details
Main Authors: Krishna Chinthalapudi, Sarah M Heissler, Matthias Preller, James R Sellers, Dietmar J Manstein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
myosin
cytoskeleton
actin
allostery
Spodoptera frugiperda
Argopecten irradians
Online Access:https://elifesciences.org/articles/32742

Internet

https://elifesciences.org/articles/32742

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