Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infection.

Pyrazinamide (PZA) is one of the first line antibiotics used for the treatment of tuberculosis (TB). In the present study, we have used in vitro and in vivo systems to investigate whether PZA, in addition to its known anti-mycobacterial properties, modulate the host immune response during Mycobacter...

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Bibliographic Details
Main Authors: Claudia Manca, Mi-Sun Koo, Blas Peixoto, Dorothy Fallows, Gilla Kaplan, Selvakumar Subbian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3755974?pdf=render