Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study

Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study

Abstract Background β-lactams are the main antibiotics used against wild-type AmpC-producing Enterobacterales (wtAE). However, they may fail or select AmpC-overproducing mutants. Our aim was to assess factors associated with clinical failure of β-lactams in the treatment of wtAE infection. Methods F...

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Bibliographic Details
Main Authors: Roman Mounier, Ronan Le Guen, Paul-Louis Woerther, Mathieu Nacher, Clément Bonnefon, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Séverine Couffin, Stéphanie Houcke, Michel Wolff, Ariane Roujansky, Caroline Schimpf, Armand Mekontso Dessap, Fabrice Cook, Keyvan Razazi, Hatem Kallel
Format: Article
Language:English
Published: SpringerOpen 2022-11-01
Series:Annals of Intensive Care
Subjects:
AmpC-producing Enterobacterales
AmpC β-lactamases
Third-generation cephalosporins
Infection
ICU
Online Access:https://doi.org/10.1186/s13613-022-01079-5

Internet

https://doi.org/10.1186/s13613-022-01079-5

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