SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD

SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD

Summary: SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYLD with the linear ubiquitylation assembly complex (LUBAC) component HOIP. Whether SPATA2 exhibits functions independently of CYLD is unclear. Here, we show that, while Cyld−/− and Spata2−/...

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Váldodahkkit: Laura Griewahn, Madeleine Müller, Lukas Peintner, Manuela Wissler, Martina Weiss, Prisca Brauns-Schubert, Ramin Massoumi, Christoph Borner, Olaf Groß, Monica Yabal, Céline Charvet, Ulrich Maurer
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Elsevier 2023-01-01
Ráidu:Cell Reports
Fáttát:
CP: Molecular biology
CP: Immunology
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2211124722018654

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http://www.sciencedirect.com/science/article/pii/S2211124722018654

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