Infusion of C20:0 ceramide into ventral hippocampus triggers anhedonia-like behavior in female and male rats

Infusion of C20:0 ceramide into ventral hippocampus triggers anhedonia-like behavior in female and male rats

Increased long-chain C20:0 ceramides have been found in the serum of patients with depression. Moreover, ceramides are linked with increased microglia reactivity and inflammatory cytokine production, which are associated with depression. Since ceramides can readily cross the blood brain barrier, per...

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Bibliographic Details
Main Authors: Lubriel Sambolín-Escobales, Adariana Feliciano-Quiñones, Lizmarie Tirado-Castro, Cristina Suárez, Dariangelly Pacheco-Cruz, Nashaly Irizarry-Méndez, Wilfred Fonseca-Ferrer, Anixa Hernández-López, María Colón-Romero, James T. Porter
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
ceramides
anhedonia model
microglia
ventral hippocampus (VH)
despair swim test
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.899627/full

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https://www.frontiersin.org/articles/10.3389/fnbeh.2022.899627/full

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