Combination of 4-1BB and DAP10 promotes proliferation and persistence of NKG2D(bbz) CAR-T cells

Combination of 4-1BB and DAP10 promotes proliferation and persistence of NKG2D(bbz) CAR-T cells

Chimeric antigen receptor (CAR)-T cell therapy has been shown to have considerable therapeutic effects in hematological malignancies, and NKG2D(z) CAR-T cell therapy has been verified to be safe based on clinical trials. However, due to the poor persistence of NKG2D(z) CAR-T cells, their therapeutic...

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Bibliographic Details
Main Authors: Cheng Wei, Kangfu Xia, Yucheng Xie, Sishi Ye, Yanghui Ding, Zairu Liu, Rong Zheng, Jing Long, Qinchuan Wei, Yumei Li, Dongxia Yang, Xiaojun Xu, Ai Zhao, Jimin Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
NKG2D
CAR-T cell
4-1BB
DAP10
PI3K
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.893124/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.893124/full

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