Determination of Genotoxic Impurity <i>N</i>-Nitroso-<i>N</i>-methyl-4-aminobutyric Acid in Four Sartan Substances through Using Liquid Chromatography–Tandem Mass Spectrometry

Determination of Genotoxic Impurity <i>N</i>-Nitroso-<i>N</i>-methyl-4-aminobutyric Acid in Four Sartan Substances through Using Liquid Chromatography–Tandem Mass Spectrometry

<i>N</i>-nitroso-<i>N</i>-methyl-4-aminobutyric acid (NMBA) is the third N-nitrosamine impurity found in sartans. Herein, a sensitive and stable LC-MS/MS method with multiple reactions monitoring mode has been developed for the quantitative determination of NMBA in four sarta...

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Bibliographic Details
Main Authors: Bin Xie, Dong Guo, Binliang Mai, Jun Fan
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
N-nitrosamine genotoxic impurity
sartan substance
<i>N</i>-nitroso-<i>N</i>-methyl-4-aminobutyric acid
LC-MS/MS quantitative determination
multiple reactions monitoring
Online Access:https://www.mdpi.com/1420-3049/27/21/7498

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https://www.mdpi.com/1420-3049/27/21/7498

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