Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease

Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease

5-hydroxyfurfural (5HMF), an allosteric effector of hemoglobin (Hb) with an ability to increase Hb affinity for oxygen has been studied extensively for its antisickling effect in vitro and in vivo, and in humans for the treatment of sickle cell disease (SCD). One of the downstream pathophysiologies...

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Bibliographic Details
Main Authors: Rana T. Alhashimi, Mohini S. Ghatge, Akua K. Donkor, Tanvi M. Deshpande, Nancy Anabaraonye, Dina Alramadhani, Richmond Danso-Danquah, Boshi Huang, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomolecules
Subjects:
hemoglobin
sickle cell disease
antisickling
nitric oxide
oxygen equilibrium curve
Online Access:https://www.mdpi.com/2218-273X/12/5/696

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https://www.mdpi.com/2218-273X/12/5/696

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