Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells

Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells

Autoimmune myocarditis often leads to dilated cardiomyopathy (DCM). Although T cell reactivity to cardiac self-antigen is common in the disease, it is unknown which antigen presenting cell (APC) triggers autoimmunity. Experimental autoimmune myocarditis (EAM) was induced by immunizing mice with α-my...

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Bibliographic Details
Main Authors: Katrien Van der Borght, Charlotte L. Scott, Liesbet Martens, Dorine Sichien, Gert Van Isterdael, Veronika Nindl, Yvan Saeys, Louis Boon, Burkhard Ludewig, Thierry C. Gillebert, Bart N. Lambrecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
myocarditis
autoimmunity
heart failure
autoreactive T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02714/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02714/full

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