Resistance to DNA repair inhibitors in cancer

The DNA damage response (DDR) represents a complex network of proteins which detect and repair DNA damage, thereby maintaining the integrity of the genome and preventing the transmission of mutations and rearranged chromosomes to daughter cells. Faults in the DDR are a known driver and hallmark of c...

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Bibliographic Details
Main Authors: Joseph S. Baxter, Diana Zatreanu, Stephen J. Pettitt, Christopher J. Lord
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Molecular Oncology
Subjects:
Online Access:https://doi.org/10.1002/1878-0261.13224