Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2

Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2

Abstract Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA) to its arabinosyl acceptor is an essential enzyme...

Full description

Bibliographic Details
Main Authors: Lu Zhang, Yao Zhao, Ruogu Gao, Jun Li, Xiuna Yang, Yan Gao, Wei Zhao, Sudagar S. Gurcha, Natacha Veerapen, Sarah M. Batt, Kajelle Kaur Besra, Wenqing Xu, Lijun Bi, Xian’en Zhang, Luke W. Guddat, Haitao Yang, Quan Wang, Gurdyal S. Besra, Zihe Rao
Format: Article
Language:English
Published: Oxford University Press 2020-05-01
Series:Protein & Cell
Subjects:
Mycobacterium tuberculosis
EmbB
cryo-EM
ethambutol
cell wall synthesis
arabinoglacatan
Online Access:https://doi.org/10.1007/s13238-020-00726-6

Internet

https://doi.org/10.1007/s13238-020-00726-6

Similar Items