BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells.

BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells.

The infusion of ex vivo-expanded autologous T regulatory (Treg) cells is potentially an effective immunotherapeutic strategy against graft-versus-host disease (GvHD) and several autoimmune diseases, such as type 1 diabetes (T1D). However, in vitro differentiation of antigen-specific T cells into fun...

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Bibliographic Details
Main Authors: Ghanashyam Sarikonda, Georgia Fousteri, Sowbarnika Sachithanantham, Jacqueline F Miller, Amy Dave, Therese Juntti, Ken T Coppieters, Matthias von Herrath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4231041?pdf=render

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http://europepmc.org/articles/PMC4231041?pdf=render

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